陳豐奇

合聘教師_陳豐奇 教授

職稱：
陽明交通大學科技法律學院合聘教授
國家衛生研究院群體健康科學研究所副所長
學歷：
國立清華大學生命科學博士
國立交通大學科技法律碩士

專業領域：
智慧財產權法、生物醫學法律、法律資訊分析

Email：
fcchen[at]nhri.edu.tw

  • 國家衛生研究院計算中心主任
  • 國家衛生研究院申訴委員會召集人
  • 台灣演化與計算生物學會理事、監事
  • 台灣科技法學會理事
  • 芝加哥大學訪問學人
  • 加州大學聖地牙哥分校訪問學人
  • 中國醫藥大學合聘教授
  • 國立交通大學生物科技學院合聘教授
  • 慈濟大學國際學院合聘教授

論文

  1. Wayne Chung-Chi Wang, Chih-Hsiung Chen, and Feng-Chi Chen* (2022). An AI trustworthiness maturity model for AI governance and auditing. (Accepted by IEEE SSIM 2022).
  2. 蘇崇哲，陳鋕雄，陳豐奇 (2022)； 運用開源軟體進行醫療用人工智慧模型開發之若干法律熱點。當代法律第 10 期: 6-20。
  3. 智慧醫療計畫法治小組 (2022)；數位轉型下的智慧代理人資料與模型治理規範
  4. Yu-Cheng Kang, Po-An Chen, and Feng-Chi Chen (2022). Under-sampling and over-sampling for debias in machine learning (extended abstract). The 27th International Conference on Technologies and Applications of Artificial Intelligence.
  5. Kuo-Yun Tseng, Yu-Chieh Liao, Feng-Chi Chen, Feng-Jui Chen, and Hsiu-Jung Lo. (2022). A predominant genotype of azole-resistant Candida tropicalis clinical strains. Lancet Microbe (published online) doi:10.1016/s2666-5247(22)00179-3.
  6. 李秉燊，陳豐奇 (2020)；近期美國多方複審 (IPR) 制度修正對製藥產業影響。智慧財產權月刊第 255 期：32-48。
  7. FC Chen*, PS Lee, YY Huang, HC Wu, and HY Lin. 2019. Interactions between Inter Partes Review and Hatch-Waxman Litigations. Proceedings of 2019 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology.
  8. 陳豐奇，陳鋕雄 (2019)； 人工智慧法律科技對律師倫理的衝擊。全國律師月刊 2019 年 9 月號: 40-42。
  9. FC Chen* and Pin-Shen Lee. 2019. Inter Partes Review: patent killer no more? Trends in Biotechnology 37(7): 680-683.
  10. YH Yang, PJ Cheng*, and FC Chen*. 2019. Predicting institution decisions in inter partes review proceedings. Journal of Patent and Trademark Office Society 100 (4): 697-717.
  11. FC Chen*. 2018. China: the next pharmacy of the world? Trends in Pharmacological Sciences 39 (10): 843-848.
  12. Pan CL and Chen FC*. 2017. Patent trend and competitive analysis of cancer immunotherapy in the United States. Human Vaccines and Immunotherapeutics 13(11):2583-2593.
  13. Hsu MK, Lin HY, and Chen FC*. 2017. NMD Classifier: A reliable and systematic classification tool for nonsense-mediated decay events. PLoS One 12(4):e0174798.
  14. Chen FC*. 2017. The challenges of joint performance to method patents. Expert Opinion on Therapeutic Patents 27(4): 393-399.
  15. Chen FC* and Yeh GL. 2016. Invalidation of atorvastatin patent highlights complex Chinese patent law. Trends in Pharmacological Sciences 37(11):883-886.
  16. Chen FC*. 2016. Divided infringement in the limelight of the patent battle field. Trends in Biotechnology 34 (10): 771-773.
  17. Chiu CF, Chang YW, KT, Liu CY, Yu YH, Cheng CC, Lee KY, Chen FC, Kuo TC, Ma JT, and Su JL*. NF-κB driven suppression of FOXO3a contributes to EGFR mutation-independent gefitinib resistance. Proceeding of the National Academy of Sciences 113 (18): E2526-35.
  18. Wang HY, Hsu MK, Wang KH, Tseng CP, Chen FC, and Hsu JTA*. 2016. Non-Small Cell Lung Cancer Cells Combat EGFR Tyrosine Kinase Inhibition through Immediate Adhesion-Related Responses. OncoTargets and Therapy 9:2961-73.
  19. Hsu MK, Pan CL, and Chen FC*. 2016. Functional divergence and convergence between the transcript network and gene network in lung adenocarcinoma. OncoTargets and Therapy 9: 335-347.
  20. Hsu MK, Wu IC, Cheng CC, Su JL*, Hsieh CH, Lin YS, and Chen FC*. 2015. Triple-layer dissection of the lung adenocarcinoma transcriptome – regulation of the gene, transcript, and exon levels. Oncotarget 6(30):28755-73.
  21. Wang HC, Chen FC, Wu MS, Shu HY, Sun HS, Wang YC, Su IJ, and Wu CJ. 2015. Genome sequences of three Helicobacter pylori strains from patients with gastric mucosa-associated lymphoid tissue lymphoma. Genome Announcements 3(2): e00229-15.
  22. Chen FC*. 2015. Alternative RNA structure-coupled translational regulations in tumorigenesis. International Journal of Molecular Sciences 16(1): 452-475. (invited review).
  23. Chen FC*, Pan CL, and Lin HY. 2014. Functional implications of RNA splicing for human long intergenic noncoding RNAs. Evolutionary Bioinformatics10: 219-228.
  24. Lin PS*, Chen FC, Kuo SF, and Kung YH. 2014. Assessing the relationship of evolutionary rates and functional variables by mixture estimating equations. Statistics and Probability Letters 94: 248-256.
  25. Chen FC*, Chuang TJ*, Lin HY, and Hsu MK. 2014. The evolution of the coding exome of the Arabidopsis species – the influences of DNA methylation, relative exon position, and exon length. BMC Evolutionary Biology 14: 145.
  26. Chen FC*, Liao YC, Huang JM, Lin CH, Chen YY, Dou HY, and Hsiung CA*. 2014. Pros and cons of the tuberculosis drugome approach – an empirical analysis. Plos One 9(6): e100829.
  27. Chuang TJ* and Chen FC*. 2014. DNA methylation is associated with an increased level of conservation at nondegenerate nucleotides in mammals. Molecular Biology and Evolution 31(2):387-96.
  28. Chen FC* 2014. Are all of the human exons alternatively spliced? Briefings in Bioinformatics 15 (4): 542-551.
  29. Liao YC, Chen YH, Lin HH, Mu JJ, Wu HS, Chen FC*, and Hsiung CA*. 2013. Draft Genome Sequence of NDM-1 Producing Klebsiella pneumoniae Clinical Isolate 303K. Genome Announcements 1(6):e01069-13.
  30. Wang TC and Chen FC*. 2013. The evolutionary landscape of the Mycobacterium tuberculosis Gene 518(1):187-93.
  31. Hsu MK and Chen FC*. Selective constraint on the upstream open reading frames that overlap with coding sequences in animals. Plos One 7(11): e48413.
  32. Chuang TJ*, Chen FC*, and Chen YZ. 2012. Position-dependent correlations between the level of DNA methylation and the evolutionary rates of mammalian coding exons. Proceedings of the National Academy of Sciences 109(39):15841-6.
  33. Gelly J-C, Lin HY, de Brevern A.G.*, Chuang TJ*, and Chen FC*. 2012. Selective Constraint on Human Pre-mRNA Splicing by Protein Structural Properties. Genome Biology and Evolution 4(9):966-75.
  34. Wu GCT and Chen FC*. 2012. Determinants of exon-level evolutionary rates in Arabidopsis Evolutionary Bioinformatics 2012 (8): 389-415.
  35. Liao YC, Tsai MH, Chen FC, and Hsiung CA. 2012. GEMSiRV: A software platform for GEnome-scale Metabolic model Simulation, Reconstruction and Visualization. Bioinformatics 28(13):1752-8.
  36. Wang MC, Chen FC*, Chen YZ, Huang YT, and Chuang TJ*. 2012. LDGIdb: a database of gene interactions inferred from long-range strong linkage disequilibrium between pairs of SNPs. BMC Research Notes 5: 212.
  37. Chen FC*, Liao BY*, Pan CL, Lin HY, and Chang AYF. 2012. Assessing determinants of exonic evolutionary rates in mammals. Molecular Biology and Evolution 29(10):3121-9.
  38. Chen FC*, Pan CL, and Lin HY. 2012. Independent effects of alternative splicing and structural constraint on the evolution of mammalian coding exons. Molecular Biology and Evolution 29(1):187-93.
  39. Lin CH, Hsiung CA*, and Chen FC*. 2011. Changes in transcriptional orientation are associated with increases in evolutionary rates of enterobacterial genes. BMC Bioinformatics 12 (Suppl 9):
  40. Chen CH, Lin HY, Pan CL, and Chen FC*. 2011. The genomic features that affect the lengths of 5’ untranslated regions in multicellular eukaryotes. BMC Bioinformatics 12 (Suppl9):S3
  41. Chen CH, Lin HY, Pan CL, and Chen FC*. 2011. The Length Evolution of 5’ Untranslated Regions – the Stochastic Model Revisited. (IEEE Proceedings of Bioinformatics and Bioengineering)
  42. Chen CH, Lin HY, Pan CL, and Chen FC*. 2011. The plausible reason why the length of 5′ untranslated region is unrelated to organismal complexity. BMC Research Notes 4:312
  43. Chen CH, Lin HY, Pan CL, and Chen FC*. 2011. Exploring the selective constraint on the sizes of insertions and deletions in 5’ untranslated regions in mammals. BMC Evolutionary Biology11: 192
  44. Liao YC, Chen JCY, Tsai MH, Tang YH, Chen FC*, and Hsiung CA*. 2011. MrBac: A web server for draft metabolic network reconstructions for bacteria. Bioengineered Bugs 2(5)
  45. Liao YC, Huang TW, Chen FC, Charusanti P, Hong JSJ, Tsai SF, Hsiung CA, Palsson BO. 2011. An experimentally validated genome-scale metabolic reconstruction of Klebsiella pneumoniae MGH 78578, i Journal of Bacteriology 193(7): 1710-7.
  46. Thiele I, Hyduke D, Steeb B, Fankam G, Douglas K. Allen, Susanna Bazzani, Pep Charusanti, Chen FC, Fleming RMT, Hsiung CA, De Keersmaecker SCJ, Liao YC, Marchal K, Mo ML, Ö zdemir E, Raghunathan A, Reed JL, Shin SI, Sigurbjörnsdóttir S, Steinmann J, Sudarsan S, Swainston N, Thijs IM, Zengler K, Palsson BO, Adkins JN, and Bumann D. 2011. A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2. BMC Systems Biology 5: 8.
  47. Liao YC, Chen FC and Hsiung CA. 2010. Contrasting substitution patterns between HA proteins of avian and human influenza viruses: implication for monitoring human influenza epidemics. Vaccine 28: 7890-6.
  48. Chen CC, Chen FC, and Li WH. 2010. Phosphorylated and non-phosphorylated serine and threonine residues evolve at different rates in mammals. Molecular Biology and Evolution 27(11):2548-54.
  49. Chen FC, Chen CJ, Li WH, and Chuang TJ. 2010. Gene family size conservation is a good indicator of evolutionary rates. Molecular Biology and Evolution 27(8):1750-8.
  50. Chen CH, Chuang TJ, Liao BY, and Chen FC*. 2009. Scanning for the signatures of positive selection for human–specific insertions and deletions. Genome Biology and Evolution 1: 415-9
  51. Lin FK, Pan CL, Chuang TJ*, and Chen FC*. 2009. CAPIH: A Web interface for comparative analyses and visualization of host-HIV protein-protein interactions. BMC Microbiology 9: 164.
  52. Chen FC, Chen YZ, and Chuang TJ. CNVVdb: a database of copy number variations across vertebrate genomes. Bioinformatics 25(11):1419-21.
  53. Huang YT, Chen FC*, and Chuang TJ*. 2008. Identification and analysis of ancestral hominoid transcriptome inferred from cross-species transcripts and processed pseudogene comparisons. Genome Research 18(7):1163-70.
  54. Chen FC and Chuang TJ. Nucleotide sequence divergence between humans and chimpanzees. 2008 (Invited review) Encyclopedia of Life Sciences. DOI: 10.1002/9780470015902.a0020751.
  55. Chen FC and Chuang TJ. 2007. Different alternative splicing patterns are subject to opposite selection pressure for protein reading frame preservation. BMC Evolutionary Biology 7: 179.
  56. Chen FC, Chen CJ, and Chuang TJ. 2007. INDELSCAN: a web server for comparative identification of species-specific and non-species-specific insertion/deletion events. Nucleic Acids Research (Web Server Issue): W633-8.
  57. Chen FC, Chaw SM, Tzeng YH, Wang SS, and Chuang TJ. 2007. Opposite evolutionary effects between different alternative splicing patterns. Molecular Biology and Evolution 24: 1443-6.
  58. Chen FC, Wang SS, Chaw SM, Huang YT, and Chuang TJ. 2007. Plant Gene and Alternatively Spliced Variant Annotator. A plant genome annotation pipeline for rice gene and alternatively spliced variant identification with cross-species expressed sequence tag conservation from seven plant species. Plant Physiology 143:1086-95.
  59. Chen FC, Chen CJ, Li WH, and Chuang TJ. 2007. Human-specific insertions and deletions inferred from mammalian genome sequences. Genome Research 17: 16-22.
  60. Chen FC and Chuang TJ. 2006. The effects of multiple features of alternatively spliced exons on the KA/KS ratio test. BMC Bioinformatics 7:259
  61. Chen FC, Chen CJ, Ho JY and Chuang TJ. 2006. Identification and evolutionary analysis of novel exons and alternative splicing events using cross-species EST-to-genome comparisons. BMC Bioinformatics 7: 136
  62. Chen FC, Wang SS, Chen CJ, Li WH and Chung TJ. 2006. Alternatively and constitutively spliced exons are subject to different evolutionary forces. Molecular Biology and Evolution 23:675-682
  63. Chen FC and TJ Chuang. 2005. ESTViewer: a Web interface for visualizing mouse, rat, cattle, pig, and chicken conserved ESTs in human genes and human alternatively spliced variants. Bioinformatics 21: 2510-2513.
  64. Chuang TJ, Chen FC and MY Chou. 2004. A comparative method for identification of gene structures and alternatively spliced variants. Bioinformatics 20: 3064-3079.
  65. Yu N, Chen FC, Ota S, Ramsay M, Jenkins T, Leskinen E, Pamilo P, Patthy L, Jorde LB, and Li WH. 2002. Larger Genetic Differences within Africans than between Africans and Eurasians. Genetics 161: 269-274.
  66. Gu, Z, Cavalcanti A, Chen FC, Bouman P, and Li WH. 2002. Extent of gene duplication in the genomes of Drosophila, nematode and yeast. Molecular Biology and Evolution 19:256-262.
  67. Chen FC and Li WH. Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees. American Journal of Human Genetics 68: 444-456.
  68. Chen FC, Vellender EJ, Wang H, Tzeng CS, and Li WH. 2001. Genomic divergence between human and chimpanzee estimated from large-scale alignments of genomic sequences. Journal of Heredity 92: 481-489.
  69. Shiao JC, Tzeng CS, Leu CL, and Chen FC. 1999. Enhancing the contrast and visibility of daily growth increments in fish otoliths etched by proteinase K buffer. Journal of Fish Biology 54: 302-309.